FDA drug class
Methylxanthines list
Every FDA-approved prescription drug the FDA NDC directory tags with the Methylxanthine [EPC] class, with brand names and DEA schedules.
Source: FDA NDC Directory file dated 2026-10-22. Publisher page
The FDA NDC directory lists 3 single-ingredient drugs in this class: aminophylline, caffeine, theophylline. Another 7 combination products include one of them.
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Methylxanthines (10)
| Drug | Brand names | Type | NDC listings | DEA schedule |
|---|---|---|---|---|
| Aminophylline | None listed | Single ingredient | 9 | Not controlled |
| Caffeine | None listed | Single ingredient | 15 | Not controlled |
| Theophylline | Theo-24 | Single ingredient | 51 | Not controlled |
| Acetaminophen, caffeine and dihydrocodeine | Trezix | Combination | 1 | Schedule III |
| Butalbital, acetaminophen and caffeine | Butalbital, Acetaminophen, Caffeine, Fioricet | Combination | 67 | Schedule III |
| Butalbital, acetaminophen, caffeine and codeine | None listed | Combination | 8 | Schedule III |
| Butalbital, aspirin and caffeine | None listed | Combination | 5 | Schedule III |
| Butalbital, aspirin, caffeine and codeine | Ascomp with Codeine | Combination | 4 | Schedule III |
| Ergotamine and caffeine | Cafergot | Combination | 3 | Not controlled |
| Orphenadrine, aspirin and caffeine | Norgesic Forte, Norgesic | Combination | 5 | Not controlled |
FDA established pharmacologic class: Methylxanthine [EPC].
Questions
What drugs are Methylxanthines?
The FDA NDC directory lists 3 single-ingredient drugs in this class: aminophylline, caffeine, theophylline. Another 7 combination products include one of them.
Where does this list come from?
From the established pharmacologic class (EPC) field FDA publishes for each listing in the NDC directory. A drug is listed when most of its prescription listings carry the class.
Related
- CaffeineFDA label
- TheophyllineTheo-24
- Acetaminophen, caffeine and dihydrocodeineTrezix
- Butalbital, acetaminophen and caffeineButalbital, Acetaminophen, Caffeine, Fioricet
- Butalbital, acetaminophen, caffeine and codeineFDA label
- Butalbital, aspirin and caffeineFDA label
- Butalbital, aspirin, caffeine and codeineAscomp with Codeine
- Ergotamine and caffeineCafergot
- All drug classesFDA EPC
- Controlled substances by scheduleDEA list
- Generic drug lookupFDA Orange Book
- NDC lookupFDA NDC directory
- Medicare Part D drug coverageBy plan and state