FDA label
What is digoxin used for?
The FDA-approved uses of digoxin, quoted from the Indications and Usage section of its DailyMed label.
Source: DailyMed SPL label file dated 2026-10-23. Publisher page
The FDA label for digoxin (tablet) lists 3 uses: Heart Failure in Adults; Heart Failure in Pediatric Patients; Atrial Fibrillation in Adults.
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Digoxin, tablet
Indications and Usage, quoted from the label by Amneal Pharmaceuticals of New York LLC (ANDA078556). Cross-references to other label sections are left out.
Heart Failure in Adults
Digoxin tablets are indicated for the treatment of mild to moderate heart failure in adults. Digoxin tablets increase left ventricular ejection fraction and improve heart failure symptoms as evidenced by improved exercise capacity and decreased heart failure-related hospitalizations and emergency care, while having no effect on mortality. Where possible, digoxin tablets should be used in combination with a diuretic and an angiotensin-converting enzyme (ACE) inhibitor.
Heart Failure in Pediatric Patients
Digoxin tablets increase myocardial contractility in pediatric patients with heart failure.
Atrial Fibrillation in Adults
Digoxin tablets are indicated for the control of ventricular response rate in adult patients with chronic atrial fibrillation.
Source: DailyMed label, set id dfac7f13-28be-423d-9389-9089da29da17, version 20, effective January 13, 2026. NDC 0115-9811, one of 39 listings for this product.
Digoxin, injection
Indications and Usage, quoted from the label by HF Acquisition Co LLC, DBA HealthFirst (ANDA083391). Cross-references to other label sections are left out.
1.1 Heart Failure in Adults
Digoxin is indicated for the treatment of mild to moderate heart failure in adults. Digoxin increases left ventricular ejection fraction and improves heart failure symptoms, as evidenced by improved exercise capacity and decreased heart failure-related hospitalizations and emergency care, while having no effect on mortality. Where possible, digoxin should be used in combination with a diuretic and an angiotensin-converting enzyme (ACE) inhibitor.
1.2 Atrial Fibrillation in Adults
Digoxin is indicated for the control of ventricular response rate in adult patients with chronic atrial fibrillation.
Source: DailyMed label, set id 75c99fc4-33b6-c3ce-e053-2991aa0a4d88, version 8, effective June 11, 2026. NDC 51662-1217, one of 6 listings for this product.
Digoxin, injection, solution
Indications and Usage, quoted from the label by Sandoz Inc (ANDA040481). Cross-references to other label sections are left out.
Heart Failure in Adults
Digoxin injection is indicated for the treatment of mild to moderate heart failure in adults. Digoxin injection increases left ventricular ejection fraction and improves heart failure symptoms, as evidenced by improved exercise capacity and decreased heart failure-related hospitalizations and emergency care, while having no effect on mortality. Where possible, digoxin injection should be used in combination with a diuretic and an angiotensin-converting enzyme (ACE) inhibitor.
Heart Failure in Pediatric Patients
Digoxin injection increases myocardial contractility in pediatric patients with heart failure.
Atrial Fibrillation in Adults
Digoxin injection is indicated for the control of ventricular response rate in adult patients with chronic atrial fibrillation.
Source: DailyMed label, set id 58f45aba-ff6f-43cc-bb88-be40a9f7beda, version 28, effective December 8, 2025. NDC 0781-3059, one of 2 listings for this product.
Questions
What is digoxin used for?
The FDA label for digoxin (tablet) lists 3 uses: Heart Failure in Adults; Heart Failure in Pediatric Patients; Atrial Fibrillation in Adults.
What drug class is digoxin?
FDA lists digoxin in the Cardiac Glycoside established pharmacologic class.
Does this page cover off-label uses or dosing?
No. This page shows only the Indications and Usage section of the FDA label. Ask a pharmacist or prescriber about dosing.