FDA label
What is estradiol valerate used for?
The FDA-approved uses of estradiol valerate, quoted from the Indications and Usage section of its DailyMed label.
Source: DailyMed SPL label file dated 2026-10-23. Publisher page
The FDA label says: “Estradiol valerate injection, USP is indicated in the: Treatment of moderate to severe vasomotor symptoms associated with the menopause; Treatment of moderate to severe symptoms of vulvar and vaginal atrophy associated with the menopause. When prescribing solely for the treatment of symptoms of vulvar and vaginal atrophy, topical vaginal products should be considered; Treatment of hypoestrogeni...”
Run it in Rivvi
Which 2027 plans near you dropped or restricted estradiol valerate?
Tier changes and new prior auth, step therapy or quantity limits, plan by plan.
Free to start. Opens Rivvi, the AI workspace for healthcare teams.
Estradiol Valerate, injection
Indications and Usage, quoted from the label by Xiromed, LLC (ANDA216656). Cross-references to other label sections are left out.
Estradiol valerate injection, USP is indicated in the:
- Treatment of moderate to severe vasomotor symptoms associated with the menopause.
- Treatment of moderate to severe symptoms of vulvar and vaginal atrophy associated with the menopause. When prescribing solely for the treatment of symptoms of vulvar and vaginal atrophy, topical vaginal products should be considered.
- Treatment of hypoestrogenism due to hypogonadism, castration or primary ovarian failure.
- Treatment of advanced androgen-dependent carcinoma of the prostate (for palliation only).
Source: DailyMed label, set id 2e5c7559-7420-168d-6272-92bb4d20035d, version 10, effective July 6, 2026. NDC 70700-273, one of 6 listings for this product.
Questions
What is estradiol valerate used for?
The FDA label says: “Estradiol valerate injection, USP is indicated in the: Treatment of moderate to severe vasomotor symptoms associated with the menopause; Treatment of moderate to severe symptoms of vulvar and vaginal atrophy associated with the menopause. When prescribing solely for the treatment of symptoms of vulvar and vaginal atrophy, topical vaginal products should be considered; Treatment of hypoestrogeni...”
What drug class is estradiol valerate?
FDA lists estradiol valerate in the Estrogen established pharmacologic class.
Does this page cover off-label uses or dosing?
No. This page shows only the Indications and Usage section of the FDA label. Ask a pharmacist or prescriber about dosing.