What Is Imipramine Used For? FDA-Approved Uses

The FDA label says: “Depression - For the relief of symptoms of depression. Endogenous depression is more likely to be alleviated than other depressive states. One to three weeks of treatment may be needed before optimal therapeutic effects are evident.”

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Imipramine Hydrochloride, tablet, film coated

Indications and Usage, quoted from the label by Leading Pharma, LLC (ANDA040903). Cross-references to other label sections are left out.

Depression - For the relief of symptoms of depression. Endogenous depression is more likely to be alleviated than other depressive states. One to three weeks of treatment may be needed before optimal therapeutic effects are evident.
Childhood Enuresis - May be useful as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older, after possible organic causes have been excluded by appropriate tests. In patients having daytime symptoms of frequency and urgency, examination should include voiding cystourethrography and cystoscopy, as necessary. The effectiveness of treatment may decrease with continued drug administration.

Source: DailyMed label, set id 490263ce-b4d2-428a-87da-fcd07f85499a, version 21, effective August 11, 2026. NDC 69315-133, one of 17 listings for this product.

Imipramine Pamoate, capsule

Indications and Usage, quoted from the label by Lupin Pharmaceuticals, Inc. (ANDA090444). Cross-references to other label sections are left out.

For the relief of symptoms of depression. Endogenous depression is more likely to be alleviated than other depressive states. One to three weeks of treatment may be needed before optimal therapeutic effects are evident.

Source: DailyMed label, set id d1dde497-1889-4424-af18-da7ca6459cf3, version 18, effective January 6, 2026. NDC 68180-314, one of 9 listings for this product.

Questions

What is imipramine used for?

The FDA label says: “Depression - For the relief of symptoms of depression. Endogenous depression is more likely to be alleviated than other depressive states. One to three weeks of treatment may be needed before optimal therapeutic effects are evident.”

What drug class is imipramine?

FDA lists imipramine in the Tricyclic Antidepressant established pharmacologic class.

Does this page cover off-label uses or dosing?

No. This page shows only the Indications and Usage section of the FDA label. Ask a pharmacist or prescriber about dosing.