What is methotrexate used for?

Indications and Usage, quoted from the label by Teva Pharmaceuticals USA, Inc. (ANDA081099). Cross-references to other label sections are left out.

Neoplastic Diseases

Methotrexate tablets are indicated for the:

• treatment of adults and pediatric patients with acute lymphoblastic leukemia (ALL) as part of a combination chemotherapy maintenance regimen
• treatment of adults with mycosis fungoides (cutaneous T-cell lymphoma) as a single agent or as part of a combination chemotherapy regimen
• treatment of adults with relapsed or refractory non-Hodgkin lymphomas as part of a metronomic combination chemotherapy regimen

Rheumatoid Arthritis

Methotrexate tablets are indicated for the treatment of adults with rheumatoid arthritis.

Polyarticular Juvenile Idiopathic Arthritis

Methotrexate tablets are indicated for the treatment of pediatric patients with polyarticular Juvenile Idiopathic Arthritis (pJIA).

Psoriasis

Methotrexate tablets are indicated for the treatment of adults with severe psoriasis.

Source: DailyMed label, set id 9b34b1d8-d125-41a2-9f6f-3fab67b573bd, version 17, effective June 4, 2026. NDC 0555-0572, one of 25 listings for this product.

Indications and Usage, quoted from the label by Alembic Pharmaceuticals Limited (ANDA220225). Cross-references to other label sections are left out.

Acute Lymphoblastic Leukemia

Methotrexate Injection is indicated for the treatment of adult and pediatric patients with acute lymphoblastic leukemia (ALL) as part of a combination chemotherapy regimen.

Meningeal Leukemia: Prophylaxis and Treatment

Methotrexate Injection is indicated for the prophylaxis and treatment of meningeal leukemia in adult and pediatric patients.

Non-Hodgkin Lymphoma

Methotrexate Injection is indicated for the treatment of adults and pediatric patients with non-Hodgkin lymphoma.

Osteosarcoma

Methotrexate Injection is indicated for the treatment of adults and pediatric patients with osteosarcoma as part of a combination chemotherapy regimen.

Breast Cancer

Methotrexate Injection is indicated for the treatment of adults with breast cancer as part of a combination chemotherapy regimen.

Squamous Cell Carcinoma of the Head and Neck

Methotrexate Injection is indicated for the treatment of adults with squamous cell carcinoma of the head and neck as a single agent.

Gestational Trophoblastic Neoplasia

Methotrexate Injection is indicated for the treatment of adults with gestational trophoblastic neoplasia (GTN) as part of a combination chemotherapy regimen.

Rheumatoid Arthritis

Methotrexate Injection is indicated for the treatment of adults with rheumatoid arthritis (RA).

Polyarticular Juvenile Idiopathic Arthritis

Methotrexate Injection is indicated for the treatment of pediatric patients with polyarticular Juvenile Idiopathic Arthritis (pJIA).

Psoriasis

Methotrexate Injection is indicated for the treatment of adults with severe psoriasis.

Source: DailyMed label, set id e98b2abd-8068-482e-9ce3-1ab262f0838e, version 1, effective April 16, 2026. NDC 46708-711, one of 12 listings for this product.