FDA label
What is Nucala used for?
Nucala contains mepolizumab. The FDA-approved uses below are quoted from the Indications and Usage section of its DailyMed label.
Source: DailyMed SPL label file dated 2026-10-23. Publisher page
The FDA label for Nucala lists 5 uses: Maintenance Treatment of Severe Asthma; Maintenance Treatment of Chronic Rhinosinusitis with Nasal Polyps; Maintenance Treatment of Chronic Obstructive Pulmonary Disease; Eosinophilic Granulomatosis with Polyangiitis; and 1 more.
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Nucala, injection, solution
Indications and Usage, quoted from the label by GlaxoSmithKline LLC (BLA761122). Cross-references to other label sections are left out.
Maintenance Treatment of Severe Asthma
NUCALA is indicated for the add-on maintenance treatment of adult and pediatric patients aged 6 years and older with severe asthma and with an eosinophilic phenotype.
Limitations of Use
NUCALA is not indicated for the relief of acute bronchospasm or status asthmaticus.
Maintenance Treatment of Chronic Rhinosinusitis with Nasal Polyps
NUCALA is indicated for the add-on maintenance treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) in adult patients aged 18 years and older with inadequate response to nasal corticosteroids.
Maintenance Treatment of Chronic Obstructive Pulmonary Disease
NUCALA is indicated for the add-on maintenance treatment of adult patients with inadequately controlled chronic obstructive pulmonary disease (COPD) and an eosinophilic phenotype.
Limitations of Use
NUCALA is not indicated for the relief of acute bronchospasm.
Eosinophilic Granulomatosis with Polyangiitis
NUCALA is indicated for the treatment of adult patients with eosinophilic granulomatosis with polyangiitis (EGPA).
Hypereosinophilic Syndrome
NUCALA is indicated for the treatment of adult and pediatric patients aged 12 years and older with hypereosinophilic syndrome (HES) for greater than or equal to 6 months without an identifiable non-hematologic secondary cause.
Source: DailyMed label, set id fefb887c-e4ac-431e-8893-e9d1a5a63fea, version 24, effective August 6, 2025. NDC 0173-0892, one of 2 listings for this product.
Questions
What is Nucala used for?
The FDA label for Nucala lists 5 uses: Maintenance Treatment of Severe Asthma; Maintenance Treatment of Chronic Rhinosinusitis with Nasal Polyps; Maintenance Treatment of Chronic Obstructive Pulmonary Disease; Eosinophilic Granulomatosis with Polyangiitis; and 1 more.
What drug class is Nucala?
FDA lists mepolizumab in the Interleukin-5 Antagonist established pharmacologic class.
Does this page cover off-label uses or dosing?
No. This page shows only the Indications and Usage section of the FDA label. Ask a pharmacist or prescriber about dosing.