FDA label
What is Orencia used for?
Orencia contains abatacept. The FDA-approved uses below are quoted from the Indications and Usage section of its DailyMed label.
Source: DailyMed SPL label file dated 2026-10-23. Publisher page
The FDA label for Orencia lists 4 uses: Adult Rheumatoid Arthritis; Polyarticular Juvenile Idiopathic Arthritis; Psoriatic Arthritis; Prophylaxis for Acute Graft versus Host Disease.
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Orencia, injection, solution
Indications and Usage, quoted from the label by E.R. Squibb & Sons, L.L.C. (BLA125118). Cross-references to other label sections are left out.
Adult Rheumatoid Arthritis
ORENCIA® is indicated for the treatment of adult patients with moderately to severely active rheumatoid arthritis (RA).
Polyarticular Juvenile Idiopathic Arthritis
ORENCIA is indicated for the treatment of patients 2 years of age and older with moderately to severely active polyarticular juvenile idiopathic arthritis (pJIA).
Psoriatic Arthritis
ORENCIA is indicated for the treatment of patients 2 years of age and older with active psoriatic arthritis (PsA).
Prophylaxis for Acute Graft versus Host Disease
ORENCIA is indicated for the prophylaxis of acute graft versus host disease (aGVHD), in combination with a calcineurin inhibitor and methotrexate, in adults and pediatric patients 2 years of age and older undergoing hematopoietic stem cell transplantation (HSCT) from a matched or 1 allele-mismatched unrelated-donor.
Limitations of Use
The concomitant use of ORENCIA with other potent immunosuppressants [e.g., biologic disease-modifying antirheumatic drugs (bDMARDs), Janus kinase (JAK) inhibitors] is not recommended.
Source: DailyMed label, set id 0836c6ac-ee37-5640-2fed-a3185a0b16eb, version 35, effective November 13, 2025. NDC 0003-2188, one of 3 listings for this product.
Questions
What is Orencia used for?
The FDA label for Orencia lists 4 uses: Adult Rheumatoid Arthritis; Polyarticular Juvenile Idiopathic Arthritis; Psoriatic Arthritis; Prophylaxis for Acute Graft versus Host Disease.
What drug class is Orencia?
FDA lists abatacept in the Selective T Cell Costimulation Modulator established pharmacologic class.
Does this page cover off-label uses or dosing?
No. This page shows only the Indications and Usage section of the FDA label. Ask a pharmacist or prescriber about dosing.
More on Orencia
- Is Orencia a controlled substance?Federal schedule
- Is Abatacept a controlled substance?Federal schedule
- Selective T Cell Costimulation Modulators listFDA drug class
- Orencia Medicare Part D coverageBy plan and state
- NDC 0003-2187Orencia NDC record
- NDC 0003-2188Orencia NDC record
- NDC 0003-2814Orencia NDC record