ICD-10-CM
ICD-10 code for Multisystem inflammatory syndrome: M35.81
The closest CDC title for "Multisystem inflammatory syndrome" is M35.81, Multisystem inflammatory syndrome. M35.81 is a billable code.
Source: CDC ICD-10-CM FY2027 order file dated June 16, 2026. Publisher page
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Codes under M35, then other CDC titles that name multisystem inflammatory syndrome
A header groups codes and is not billed. A billable code is one you can report.
- M35Other systemic involvement of connective tissueHeader
- M35.0Sjogren syndromeHeader
- M35.00Sjogren syndrome, unspecifiedBillable
- M35.01Sjogren syndrome with keratoconjunctivitisBillable
- M35.02Sjogren syndrome with lung involvementBillable
- M35.03Sjogren syndrome with myopathyBillable
- M35.04Sjogren syndrome with tubulo-interstitial nephropathyBillable
- M35.05Sjogren syndrome with inflammatory arthritisBillable
- M35.06Sjogren syndrome with peripheral nervous system involvementBillable
- M35.07Sjogren syndrome with central nervous system involvementBillable
- M35.08Sjogren syndrome with gastrointestinal involvementBillable
- M35.09Sjogren syndrome with other organ involvementBillable
- M35.0ASjogren syndrome with glomerular diseaseBillable
- M35.0BSjogren syndrome with vasculitisBillable
- M35.0CSjogren syndrome with dental involvementBillable
- M35.1Other overlap syndromesBillable
- M35.2Behcet's diseaseBillable
- M35.3Polymyalgia rheumaticaBillable
- M35.4Diffuse (eosinophilic) fasciitisBillable
- M35.5Multifocal fibrosclerosisBillable
- M35.6Relapsing panniculitis [Weber-Christian]Billable
- M35.7Hypermobility syndromeBillable
- M35.8Other specified systemic involvement of connective tissueHeader
- M35.81Multisystem inflammatory syndromeBillable
- M35.89Other specified systemic involvement of connective tissueBillable
- M35.9Systemic involvement of connective tissue, unspecifiedBillable
Code first
The CDC tabular list says to report the code named here before this one.
Code first, if applicable, COVID-19 (U07.1)
Code also
The CDC tabular list says a second code may be needed with this one. The note does not set which is listed first.
Use additional code
The CDC tabular list says to add the code named here after this one when it applies.
Use additional code, if applicable, for:
Excludes1
Excludes1 means these codes are not reported together.
From M35. A note on a category applies to every code under it.
Related conditions
Related pages
- M35.81 code detailsNotes, nearby codes, CMS-HCC group
- Category M35Every code under it
- Chapter 13Diseases of the musculoskeletal system
- ICD-10 codes by conditionA to Z
- Check a list of ICD-10 codes
- Denial code CO-11Diagnosis does not support the procedure
- Denial code CO-146Diagnosis invalid for the date of service
- HCPCS Level II code lookup
Questions
What is the ICD-10 code for Multisystem inflammatory syndrome?
The closest CDC title for "Multisystem inflammatory syndrome" is M35.81, Multisystem inflammatory syndrome. M35.81 is a billable code.
Is M35.81 billable?
Yes. M35.81 is a billable code in the FY2027 ICD-10-CM file. Use a more specific code when the record documents one.
What documentation notes apply to M35.81?
The CDC tabular list gives 1 Excludes1 note (not coded together), 4 "use additional code" notes for M35.81 and the categories above it. They are listed on this page.
What chapter is M35.81 in?
Chapter 13. Diseases of the musculoskeletal system.
When do ICD-10-CM codes change?
Every October 1, with the new fiscal year file. Some years add April 1 updates. This page uses the FY2027 file, effective October 1, 2026.