ICD-10-CM
ICD-10 code for Serum allergy, allergic reaction: T80.69
The ICD-10-CM index points "Serum allergy, allergic reaction" to T80.69, Other serum reaction due to other serum. T80.69 is not billable on its own. Add the 7th character for the encounter, for example T80.69XA, Other serum reaction due to other serum, initial encounter.
Source: CDC ICD-10-CM FY2027 Alphabetic Index file dated June 16, 2026. Publisher page
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Index subterms
A header groups codes and is not billed. A billable code is one you can report.
More specific codes in T80
A header groups codes and is not billed. A billable code is one you can report.
- T80Complications following infusion, transfusion and therapeutic injectionHeader
- T80.0Air embolism following infusion, transfusion and therapeutic injectionHeader
- T80.1Vascular complications following infusion, transfusion and therapeutic injectionHeader
- T80.2Infections following infusion, transfusion and therapeutic injectionHeader
- T80.21Infection due to central venous catheterHeader
- T80.22Acute infection following transfusion, infusion, or injection of blood and blood productsHeader
- T80.29Infection following other infusion, transfusion and therapeutic injectionHeader
- T80.3ABO incompatibility reaction due to transfusion of blood or blood productsHeader
- T80.30ABO incompatibility reaction due to transfusion of blood or blood products, unspecifiedHeader
- T80.31ABO incompatibility with hemolytic transfusion reactionHeader
- T80.39Other ABO incompatibility reaction due to transfusion of blood or blood productsHeader
- T80.4Rh incompatibility reaction due to transfusion of blood or blood productsHeader
- T80.40Rh incompatibility reaction due to transfusion of blood or blood products, unspecifiedHeader
- T80.41Rh incompatibility with hemolytic transfusion reactionHeader
- T80.49Other Rh incompatibility reaction due to transfusion of blood or blood productsHeader
- T80.5Anaphylactic reaction due to serumHeader
- T80.51Anaphylactic reaction due to administration of blood and blood productsHeader
- T80.52Anaphylactic reaction due to vaccinationHeader
- T80.59Anaphylactic reaction due to other serumHeader
- T80.6Other serum reactionsHeader
- T80.61Other serum reaction due to administration of blood and blood productsHeader
- T80.62Other serum reaction due to vaccinationHeader
- T80.69Other serum reaction due to other serumHeader
- T80.8Other complications following infusion, transfusion and therapeutic injectionHeader
- T80.81Extravasation of vesicant agentHeader
- T80.82Complication of immune effector cellular therapyHeader
- T80.89Other complications following infusion, transfusion and therapeutic injectionHeader
- T80.9Unspecified complication following infusion, transfusion and therapeutic injectionHeader
- T80.90Unspecified complication following infusion and therapeutic injectionHeader
- T80.91Hemolytic transfusion reaction, unspecified incompatibilityHeader
- T80.92Unspecified transfusion reactionHeader
- T80.ANon-ABO incompatibility reaction due to transfusion of blood or blood productsHeader
- T80.A0Non-ABO incompatibility reaction due to transfusion of blood or blood products, unspecifiedHeader
- T80.A1Non-ABO incompatibility with hemolytic transfusion reactionHeader
- T80.A9Other non-ABO incompatibility reaction due to transfusion of blood or blood productsHeader
Code also
The CDC tabular list says a second code may be needed with this one. The note does not set which is listed first.
Code also, if applicable, arthropathy in hypersensitivity reactions classified elsewhere (M36.4)
Excludes2
Excludes2 means the other condition can be reported with this one when both are documented.
From T80.6. A note on a category applies to every code under it.
From T80. A note on a category applies to every code under it.
- T86.01Bone marrow transplant rejection
- R50.84Febrile nonhemolytic transfusion reaction
- E87.71Fluid overload due to transfusion
- D69.51Posttransfusion purpura
- E87.71Transfusion associated circulatory overload (TACO)
- E83.111Transfusion (red blood cell) associated hemochromatosis
- J95.84Transfusion related acute lung injury (TRALI)
Related pages
- T80.69 code detailsNotes, nearby codes, CMS-HCC group
- Category T80Every code under it
- Chapter 19Injury, poisoning and certain other consequences
- ICD-10 codes by conditionA to Z
- Check a list of ICD-10 codes
- Denial code CO-11Diagnosis does not support the procedure
- Denial code CO-146Diagnosis invalid for the date of service
- HCPCS Level II code lookup
Questions
What is the ICD-10 code for Serum allergy, allergic reaction?
The ICD-10-CM index points "Serum allergy, allergic reaction" to T80.69, Other serum reaction due to other serum. T80.69 is not billable on its own. Add the 7th character for the encounter, for example T80.69XA, Other serum reaction due to other serum, initial encounter.
Is T80.69 billable?
No. T80.69 is a header in the FY2027 CDC file. Report a more specific code under it.
What documentation notes apply to T80.69?
The CDC tabular list gives 8 Excludes2 notes (may be coded together when both are documented) for T80.69 and the categories above it. They are listed on this page.
What chapter is T80.69 in?
Chapter 19. Injury, poisoning and certain other consequences.
When do ICD-10-CM codes change?
Every October 1, with the new fiscal year file. Some years add April 1 updates. This page uses the FY2027 file, effective October 1, 2026.