ICD-10-CM
ICD-10 code for Sickle cell disease: D57.1
The closest CDC title for "Sickle cell disease" is D57.1, Sickle-cell disease without crisis. D57.1 is a billable code.
Source: CDC ICD-10-CM FY2027 order file dated June 16, 2026. Publisher page
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Codes under D57, then other CDC titles that name sickle-cell disease without crisis
A header groups codes and is not billed. A billable code is one you can report.
- D57Sickle-cell disordersHeader
- D57.0Hb-SS disease with crisisHeader
- D57.00Hb-SS disease with crisis, unspecifiedBillable
- D57.01Hb-SS disease with acute chest syndromeBillable
- D57.02Hb-SS disease with splenic sequestrationBillable
- D57.03Hb-SS disease with cerebral vascular involvementBillable
- D57.04Hb-SS disease with dactylitisBillable
- D57.09Hb-SS disease with crisis with other specified complicationBillable
- D57.1Sickle-cell disease without crisisBillable
- D57.2Sickle-cell/Hb-C diseaseHeader
- D57.20Sickle-cell/Hb-C disease without crisisBillable
- D57.21Sickle-cell/Hb-C disease with crisisHeader
- D57.211Sickle-cell/Hb-C disease with acute chest syndromeBillable
- D57.212Sickle-cell/Hb-C disease with splenic sequestrationBillable
- D57.213Sickle-cell/Hb-C disease with cerebral vascular involvementBillable
- D57.214Sickle-cell/Hb-C disease with dactylitisBillable
- D57.218Sickle-cell/Hb-C disease with crisis with other specified complicationBillable
- D57.219Sickle-cell/Hb-C disease with crisis, unspecifiedBillable
- D57.3Sickle-cell traitBillable
- D57.4Sickle-cell thalassemiaHeader
- D57.40Sickle-cell thalassemia without crisisBillable
- D57.41Sickle-cell thalassemia, unspecified, with crisisHeader
- D57.411Sickle-cell thalassemia, unspecified, with acute chest syndromeBillable
- D57.412Sickle-cell thalassemia, unspecified, with splenic sequestrationBillable
- D57.413Sickle-cell thalassemia, unspecified, with cerebral vascular involvementBillable
- D57.414Sickle-cell thalassemia, unspecified, with dactylitisBillable
- D57.418Sickle-cell thalassemia, unspecified, with crisis with other specified complicationBillable
- D57.419Sickle-cell thalassemia, unspecified, with crisisBillable
- D57.42Sickle-cell thalassemia beta zero without crisisBillable
- D57.43Sickle-cell thalassemia beta zero with crisisHeader
- D57.431Sickle-cell thalassemia beta zero with acute chest syndromeBillable
- D57.432Sickle-cell thalassemia beta zero with splenic sequestrationBillable
- D57.433Sickle-cell thalassemia beta zero with cerebral vascular involvementBillable
- D57.434Sickle-cell thalassemia beta zero with dactylitisBillable
- D57.438Sickle-cell thalassemia beta zero with crisis with other specified complicationBillable
- D57.439Sickle-cell thalassemia beta zero with crisis, unspecifiedBillable
- D57.44Sickle-cell thalassemia beta plus without crisisBillable
- D57.45Sickle-cell thalassemia beta plus with crisisHeader
- D57.451Sickle-cell thalassemia beta plus with acute chest syndromeBillable
- D57.452Sickle-cell thalassemia beta plus with splenic sequestrationBillable
- D57.453Sickle-cell thalassemia beta plus with cerebral vascular involvementBillable
- D57.454Sickle-cell thalassemia beta plus with dactylitisBillable
- D57.458Sickle-cell thalassemia beta plus with crisis with other specified complicationBillable
- D57.459Sickle-cell thalassemia beta plus with crisis, unspecifiedBillable
- D57.8Other sickle-cell disordersHeader
- D57.80Other sickle-cell disorders without crisisBillable
- D57.81Other sickle-cell disorders with crisisHeader
- D57.811Other sickle-cell disorders with acute chest syndromeBillable
- D57.812Other sickle-cell disorders with splenic sequestrationBillable
- D57.813Other sickle-cell disorders with cerebral vascular involvementBillable
- D57.814Other sickle-cell disorders with dactylitisBillable
- D57.818Other sickle-cell disorders with crisis with other specified complicationBillable
- D57.819Other sickle-cell disorders with crisis, unspecifiedBillable
Use additional code
The CDC tabular list says to add the code named here after this one when it applies.
From D57. A note on a category applies to every code under it.
Use additional code for any associated fever (R50.81)
Excludes1
Excludes1 means these codes are not reported together.
From D57. A note on a category applies to every code under it.
Related conditions
Related pages
- D57.1 code detailsNotes, nearby codes, CMS-HCC group
- Category D57Every code under it
- Chapter 3Diseases of the blood and blood-forming organs
- ICD-10 codes by conditionA to Z
- Check a list of ICD-10 codes
- Denial code CO-11Diagnosis does not support the procedure
- Denial code CO-146Diagnosis invalid for the date of service
- HCPCS Level II code lookup
Questions
What is the ICD-10 code for Sickle cell disease?
The closest CDC title for "Sickle cell disease" is D57.1, Sickle-cell disease without crisis. D57.1 is a billable code.
Is D57.1 billable?
Yes. D57.1 is a billable code in the FY2027 ICD-10-CM file. Use a more specific code when the record documents one.
What documentation notes apply to D57.1?
The CDC tabular list gives 1 Excludes1 note (not coded together), 1 "use additional code" note for D57.1 and the categories above it. They are listed on this page.
What chapter is D57.1 in?
Chapter 3. Diseases of the blood and blood-forming organs.
When do ICD-10-CM codes change?
Every October 1, with the new fiscal year file. Some years add April 1 updates. This page uses the FY2027 file, effective October 1, 2026.