ICD-10-CM
ICD-10 code for Syndrome cytokine release: D89.839
The ICD-10-CM index points "Syndrome cytokine release" to D89.839, Cytokine release syndrome, grade unspecified. D89.839 is a billable code.
Source: CDC ICD-10-CM FY2027 Alphabetic Index file dated June 16, 2026. Publisher page
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Index subterms
A header groups codes and is not billed. A billable code is one you can report.
More specific codes in D89
A header groups codes and is not billed. A billable code is one you can report.
- D89Other disorders involving the immune mechanism, not elsewhere classifiedHeader
- D89.0Polyclonal hypergammaglobulinemiaBillable
- D89.1CryoglobulinemiaBillable
- D89.2Hypergammaglobulinemia, unspecifiedBillable
- D89.3Immune reconstitution syndromeBillable
- D89.4Mast cell activation syndrome and related disordersHeader
- D89.40Mast cell activation, unspecifiedBillable
- D89.41Monoclonal mast cell activation syndromeBillable
- D89.42Idiopathic mast cell activation syndromeBillable
- D89.43Secondary mast cell activationBillable
- D89.44Hereditary alpha tryptasemiaBillable
- D89.49Other mast cell activation disorderBillable
- D89.8Other specified disorders involving the immune mechanism, not elsewhere classifiedHeader
- D89.81Graft-versus-host diseaseHeader
- D89.810Acute graft-versus-host diseaseBillable
- D89.811Chronic graft-versus-host diseaseBillable
- D89.812Acute on chronic graft-versus-host diseaseBillable
- D89.813Graft-versus-host disease, unspecifiedBillable
- D89.82Autoimmune lymphoproliferative syndrome [ALPS]Billable
- D89.83Cytokine release syndromeHeader
- D89.831Cytokine release syndrome, grade 1Billable
- D89.832Cytokine release syndrome, grade 2Billable
- D89.833Cytokine release syndrome, grade 3Billable
- D89.834Cytokine release syndrome, grade 4Billable
- D89.835Cytokine release syndrome, grade 5Billable
- D89.839Cytokine release syndrome, grade unspecifiedBillable
- D89.84IgG4-related diseaseBillable
- D89.89Other specified disorders involving the immune mechanism, not elsewhere classifiedBillable
- D89.9Disorder involving the immune mechanism, unspecifiedBillable
Code first
The CDC tabular list says to report the code named here before this one.
From D89.83. A note on a category applies to every code under it.
Code first underlying cause, such as:
Use additional code
The CDC tabular list says to add the code named here after this one when it applies.
From D89.83. A note on a category applies to every code under it.
Use additional code for adverse effect, if applicable, to identify immune checkpoint inhibitors and immunostimulant drugs (T45.AX5)
Use additional code to identify associated manifestations
Excludes1
Excludes1 means these codes are not reported together.
From D89. A note on a category applies to every code under it.
Excludes2
Excludes2 means the other condition can be reported with this one when both are documented.
From D89. A note on a category applies to every code under it.
Related conditions
Related pages
- D89.839 code detailsNotes, nearby codes, CMS-HCC group
- Category D89Every code under it
- Chapter 3Diseases of the blood and blood-forming organs
- ICD-10 codes by conditionA to Z
- Check a list of ICD-10 codes
- Denial code CO-11Diagnosis does not support the procedure
- Denial code CO-146Diagnosis invalid for the date of service
- HCPCS Level II code lookup
Questions
What is the ICD-10 code for Syndrome cytokine release?
The ICD-10-CM index points "Syndrome cytokine release" to D89.839, Cytokine release syndrome, grade unspecified. D89.839 is a billable code.
Is D89.839 billable?
Yes. D89.839 is a billable code in the FY2027 ICD-10-CM file. Use a more specific code when the record documents one.
What documentation notes apply to D89.839?
The CDC tabular list gives 2 Excludes1 notes (not coded together), 1 Excludes2 note (may be coded together when both are documented), 2 "use additional code" notes for D89.839 and the categories above it. They are listed on this page.
What chapter is D89.839 in?
Chapter 3. Diseases of the blood and blood-forming organs.
When do ICD-10-CM codes change?
Every October 1, with the new fiscal year file. Some years add April 1 updates. This page uses the FY2027 file, effective October 1, 2026.