HCPCS Level II modifier
Modifier ZC
Modifier ZC is a HCPCS Level II modifier. CMS describes it as: Merck/samsung bioepis.
Source: CMS HCPCS Level II, October 2026 file dated September 23, 2026. Publisher page
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- Modifier
- ZC
- Type
- HCPCS Level II modifier, maintained by CMS
- CMS description
- Merck/samsung bioepis
- Claim form
- CMS-1500 item 24D, up to four modifiers per line. 837P SV101-3 to SV101-6.
- Guidance
- CMS HCPCS quarterly update
Related modifiers
- ZBPfizer/hospira
- ZANovartis/sandoz
- XUUnusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
- XSSeparate structure, a service that is distinct because it was performed on a separate organ/structure
- XPSeparate practitioner, a service that is distinct because it was performed by a different practitioner
- XESeparate encounter, a service that is distinct because it occurred during a separate encounter
- X5Diagnostic services requested by another clinician: for reporting services by a clinician who furnishes care to the patient only as requested by another clinician or subsequent and related services requested by another clinician; this modifier is reported for patient relationships that may not be adequately captured by the above alternative categories; reporting clinician service examples include but are not limited to, the radiologist's interpretation of an imaging study requested by another clinician
- X4Episodic/focused services: for reporting services by clinicians who provide focused care on particular types of treatment limited to a defined period and circumstance; the patient has a problem, acute or chronic, that will be treated with surgery, radiation, or some other type of generally time-limited intervention; reporting clinician service examples include but are not limited to, the orthopedic surgeon performing a knee replacement and seeing the patient through the postoperative period
Related pages
Questions
What does modifier ZC mean?
Modifier ZC is a HCPCS Level II modifier. CMS describes it as: Merck/samsung bioepis.
Is modifier ZC a CPT or a HCPCS modifier?
ZC is a HCPCS Level II modifier from the CMS quarterly HCPCS file. Two-digit numeric modifiers, such as 25 or 59, are CPT modifiers.
Where does modifier ZC go on a claim?
On the CMS-1500 it goes in item 24D next to the procedure code. Each line holds up to four modifiers. On an 837P it goes in SV101-3 to SV101-6.
What denial comes back when a modifier is wrong?
A missing or mismatched modifier often comes back as CARC 4. A modifier that was not valid on the date of service comes back as CARC 182. A bundling edit the modifier should have bypassed comes back as CARC 97 or 236.