Is Estradiol a Controlled Substance? No

No. Estradiol is not a federally controlled substance. None of its FDA NDC listings carries a DEA schedule, and estradiol is not on the DEA controlled substances list.

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Schedule check

Schedule sources for Estradiol
Source	What it lists
FDA NDC directory	258 prescription listings from 47 labelers, none with a DEA schedule
DEA controlled substances list	estradiol is not on the list

Estradiol NDC listings

NDC listings for Estradiol
NDC	Product	Form	Strength	Labeler	DEA schedule
50419-454	Climara	patch	.025 mg/d	Bayer HealthCare Pharmaceuticals Inc.	None
50419-456	Climara	patch	.0375 mg/d	Bayer HealthCare Pharmaceuticals Inc.	None
50419-451	Climara	patch	.05 mg/d	Bayer HealthCare Pharmaceuticals Inc.	None
50419-459	Climara	patch	.06 mg/d	Bayer HealthCare Pharmaceuticals Inc.	None
50419-453	Climara	patch	.075 mg/d	Bayer HealthCare Pharmaceuticals Inc.	None
50419-452	Climara	patch	.1 mg/d	Bayer HealthCare Pharmaceuticals Inc.	None
68025-065	DIVIGEL	gel	.25 mg/.25g	Vertical Pharmaceuticals, LLC	None
68025-066	DIVIGEL	gel	.5 mg/.5g	Vertical Pharmaceuticals, LLC	None
68025-083	DIVIGEL	gel	.75 mg/.75g	Vertical Pharmaceuticals, LLC	None
68025-067	DIVIGEL	gel	1 mg/g	Vertical Pharmaceuticals, LLC	None
68025-086	DIVIGEL	gel	1.25 mg/1.25g	Vertical Pharmaceuticals, LLC	None
0037-4801	ELESTRIN	gel, metered	.52 mg/.87g	Viatris Specialty LLC	None
13811-090	Estradiol	gel	.25 mg/.25g	Trigen Laboratories, LLC	None
13811-091	Estradiol	gel	.5 mg/.5g	Trigen Laboratories, LLC	None
13811-092	Estradiol	gel	.75 mg/.75g	Trigen Laboratories, LLC	None
13811-093	Estradiol	gel	1 mg/g	Trigen Laboratories, LLC	None
13811-094	Estradiol	gel	1.25 mg/1.25g	Trigen Laboratories, LLC	None
0013-1042	Estring	system	2 mg/1	Pfizer Laboratories Div Pfizer Inc	None
17139-617	EstroGel	gel, metered	.75 mg/1.25g	ASCEND Therapeutics US, LLC	None
0574-2067	Evamist	spray	1.53 mg/1	Padagis US LLC	None
50419-455	Menostar	patch	14 ug/d	Bayer HealthCare Pharmaceuticals Inc.	None
68968-6625	Minivelle	film, extended release	.025 mg/d	Noven Therapeutics, LLC	None
68968-6637	Minivelle	film, extended release	.0375 mg/d	Noven Therapeutics, LLC	None
68968-6650	Minivelle	film, extended release	.05 mg/d	Noven Therapeutics, LLC	None
68968-6675	Minivelle	film, extended release	.075 mg/d	Noven Therapeutics, LLC	None
68968-6610	Minivelle	film, extended release	.1 mg/d	Noven Therapeutics, LLC	None
0169-5176	Vagifem	insert	10 ug/1	Novo Nordisk	None
66758-145	Vivelle-Dot	patch, extended release	.025 mg/d	Sandoz Inc	None
66758-146	Vivelle-Dot	patch, extended release	.0375 mg/d	Sandoz Inc	None
66758-147	Vivelle-Dot	patch, extended release	.05 mg/d	Sandoz Inc	None
66758-148	Vivelle-Dot	patch, extended release	.075 mg/d	Sandoz Inc	None
66758-149	Vivelle-Dot	patch, extended release	.1 mg/d	Sandoz Inc	None
65162-989	DOTTI	patch, extended release	.025 mg/d	Amneal Pharmaceuticals LLC	None
72162-2032	DOTTI	patch, extended release	.025 mg/d	Bryant Ranch Prepack	None
65162-992	DOTTI	patch, extended release	.0375 mg/d	Amneal Pharmaceuticals LLC	None
72162-2033	DOTTI	patch, extended release	.0375 mg/d	Bryant Ranch Prepack	None
65162-993	DOTTI	patch, extended release	.05 mg/d	Amneal Pharmaceuticals LLC	None
72162-2034	DOTTI	patch, extended release	.05 mg/d	Bryant Ranch Prepack	None
65162-995	DOTTI	patch, extended release	.075 mg/d	Amneal Pharmaceuticals LLC	None
72162-2035	DOTTI	patch, extended release	.075 mg/d	Bryant Ranch Prepack	None

Showing 40 of 258 listings.

Questions

Is estradiol a controlled substance?

No. Estradiol is not a federally controlled substance. None of its FDA NDC listings carries a DEA schedule, and estradiol is not on the DEA controlled substances list.

Is estradiol a narcotic?

No. Estradiol is not on the DEA controlled substances list, so the DEA does not classify it as a narcotic. Its FDA established pharmacologic class is Estrogen.

Does this page cover state schedules?

No. This page reports the federal schedule only. Some states schedule drugs on their own; check your state board of pharmacy.