DEA schedule
Is Motofen a controlled substance?
Motofen contains difenoxin and atropine. Federal schedule from the FDA NDC directory, checked against the DEA controlled substances list.
Source: FDA NDC Directory file dated 2026-10-22. Publisher page
Yes. Motofen (difenoxin and atropine) is a Schedule IV controlled substance under the federal Controlled Substances Act. Matching DEA list entry: Difenoxin 1 mg/25 ug AtSO4/du (Schedule IV).
Run it in Rivvi
Which 2027 plans near you dropped or restricted Motofen?
Tier changes and new prior auth, step therapy or quantity limits, plan by plan.
Free to start. Opens Rivvi, the AI workspace for healthcare teams.
Schedule check
| Source | What it lists |
|---|---|
| FDA NDC directory | 2 prescription listings from 2 labelers, all Schedule IV |
| DEA controlled substances list | Difenoxin: Schedule I; Difenoxin 1 mg/25 ug AtSO4/du: Schedule IV; Difenoxin preparations - 0.5 mg/25 ug AtSO4/du: Schedule V |
DEA list entry
| Substance | DEA code | Schedule | Narcotic | Other names | Match |
|---|---|---|---|---|---|
| Difenoxin | 9168 | I | Yes | Lyspafen | Listed by name |
| Difenoxin 1 mg/25 ug AtSO4/du | 9167 | IV | Yes | Motofen | Listed combination or preparation |
| Difenoxin preparations - 0.5 mg/25 ug AtSO4/du | None | V | Yes | Motofen | Listed combination or preparation |
Motofen NDC listings
Questions
Is Motofen a controlled substance?
Yes. Motofen (difenoxin and atropine) is a Schedule IV controlled substance under the federal Controlled Substances Act. Matching DEA list entry: Difenoxin 1 mg/25 ug AtSO4/du (Schedule IV).
Is Motofen a narcotic?
Yes. The DEA list marks difenoxin and atropine as a narcotic (NARC = Y) and places it in Schedule IV. Its FDA established pharmacologic class is Anticholinergic and Antidiarrheal and Cholinergic Muscarinic Antagonist.
What schedule is Motofen?
Motofen is Schedule IV in the FDA NDC directory, which matches the DEA controlled substances list.
Does this page cover state schedules?
No. This page reports the federal schedule only. Some states schedule drugs on their own; check your state board of pharmacy.
More on Motofen
- What is Motofen used for?FDA label uses
- Generic for MotofenFDA Orange Book
- Is Difenoxin and Atropine a controlled substance?Schedule IV
- Anticholinergics listFDA drug class
- Antidiarrheals listFDA drug class
- Cholinergic Muscarinic Antagonists listFDA drug class
- NDC 54766-200Motofen NDC record
- NDC 83107-011Motofen NDC record
- Schedule IV drugs listDEA schedule