Is Xywav a Controlled Substance? Schedule III

Yes. Xywav (sodium oxybate, calcium oxybate, potassium oxybate and magnesium oxybate) is a Schedule III controlled substance under the federal Controlled Substances Act. Matching DEA list entry: Gamma Hydroxybutyric Acid preparations (Schedule III).

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Schedule check

Schedule sources for Xywav
Source	What it lists
FDA NDC directory	1 prescription listings from 1 labelers, all Schedule III
DEA controlled substances list	Gamma Hydroxybutyric Acid: Schedule I; Gamma Hydroxybutyric Acid preparations: Schedule III

DEA list entry

DEA list entries for sodium oxybate, calcium oxybate, potassium oxybate and magnesium oxybate
Substance	DEA code	Schedule	Narcotic	Other names	Match
Gamma Hydroxybutyric Acid	2010	I	No	GHB; gamma hydroxybutyrate; sodium oxybate	Isomer or salt of the listed substance (21 CFR 1308)
Gamma Hydroxybutyric Acid preparations	2012	III	No	Xyrem	Listed combination or preparation
Gamma Hydroxybutyric Acid	2010	I	No	GHB; gamma hydroxybutyrate; sodium oxybate	Isomer or salt of the listed substance (21 CFR 1308)
Gamma Hydroxybutyric Acid preparations	2012	III	No	Xyrem	Listed combination or preparation
Gamma Hydroxybutyric Acid	2010	I	No	GHB; gamma hydroxybutyrate; sodium oxybate	Isomer or salt of the listed substance (21 CFR 1308)
Gamma Hydroxybutyric Acid preparations	2012	III	No	Xyrem	Listed combination or preparation
Gamma Hydroxybutyric Acid	2010	I	No	GHB; gamma hydroxybutyrate; sodium oxybate	Isomer or salt of the listed substance (21 CFR 1308)
Gamma Hydroxybutyric Acid preparations	2012	III	No	Xyrem	Listed combination or preparation

Xywav NDC listings

NDC listings for Xywav
NDC	Product	Form	Strength	Labeler	DEA schedule
68727-150	XYWAV	solution	.5 g/mL; .5 g/mL; .5 g/mL; .5 g/mL	Jazz Pharmaceuticals, Inc.	CIII

Questions

Is Xywav a controlled substance?

Yes. Xywav (sodium oxybate, calcium oxybate, potassium oxybate and magnesium oxybate) is a Schedule III controlled substance under the federal Controlled Substances Act. Matching DEA list entry: Gamma Hydroxybutyric Acid preparations (Schedule III).

Is Xywav a narcotic?

No. The DEA list does not mark sodium oxybate, calcium oxybate, potassium oxybate and magnesium oxybate as a narcotic (NARC = N) and places it in Schedule III. Its FDA established pharmacologic class is Central Nervous System Depressant.

What schedule is Xywav?

Xywav is Schedule III in the FDA NDC directory, which matches the DEA controlled substances list.

Does this page cover state schedules?

No. This page reports the federal schedule only. Some states schedule drugs on their own; check your state board of pharmacy.