FDA drug class
Opioid Antagonists list
Every FDA-approved prescription drug the FDA NDC directory tags with the Opioid Antagonist [EPC] class, with brand names and DEA schedules.
Source: FDA NDC Directory file dated 2026-10-22. Publisher page
The FDA NDC directory lists 7 single-ingredient drugs in this class: alvimopan, methylnaltrexone bromide, naldemedine, nalmefene, naloxegol, naloxone, naltrexone. Another 4 combination products include one of them.
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Opioid Antagonists (11)
| Drug | Brand names | Type | NDC listings | DEA schedule |
|---|---|---|---|---|
| Alvimopan | None listed | Single ingredient | 4 | Not controlled |
| Methylnaltrexone bromide | Relistor | Single ingredient | 3 | Not controlled |
| Naldemedine | Symproic | Single ingredient | 1 | Not controlled |
| Nalmefene | Opvee | Single ingredient | 5 | Not controlled |
| Naloxegol | Movantik | Single ingredient | 3 | Not controlled |
| Naloxone | Narcan, Kloxxado, Zimhi, Rezenopy | Single ingredient | 72 | Not controlled |
| Naltrexone | None listed | Single ingredient | 45 | Not controlled |
| Buprenorphine and naloxone | Suboxone, Zubsolv | Combination | 104 | Schedule III |
| Naltrexone and bupropion | Contrave | Combination | 1 | Not controlled |
| Olanzapine and samidorphan l-malate | Lybalvi | Combination | 4 | Not controlled |
| Pentazocine and naloxone | None listed | Combination | 3 | Schedule IV |
FDA established pharmacologic class: Opioid Antagonist [EPC].
Questions
What drugs are Opioid Antagonists?
The FDA NDC directory lists 7 single-ingredient drugs in this class: alvimopan, methylnaltrexone bromide, naldemedine, nalmefene, naloxegol, naloxone, naltrexone. Another 4 combination products include one of them.
Where does this list come from?
From the established pharmacologic class (EPC) field FDA publishes for each listing in the NDC directory. A drug is listed when most of its prescription listings carry the class.
Related
- AlvimopanFDA label
- Methylnaltrexone bromideRelistor
- NaldemedineSymproic
- NalmefeneOpvee
- NaloxegolMovantik
- NaloxoneNarcan, Kloxxado
- NaltrexoneFDA label
- Buprenorphine and naloxoneSuboxone, Zubsolv
- All drug classesFDA EPC
- Controlled substances by scheduleDEA list
- Generic drug lookupFDA Orange Book
- NDC lookupFDA NDC directory
- Medicare Part D drug coverageBy plan and state