Medicare drug coverage
Zenpep: 2027 Medicare Part D coverage
5,220 of 5,495 Part D plans (95%) list Zenpep on their 2027 formulary, the plan's list of covered drugs (up 1 point from 2026). <1% of those require prior authorization, step therapy, or a quantity limit. Plan counts include both Medicare Advantage plans with drug coverage (5,172 MA-PD) and stand-alone drug plans (323 PDP).
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Data only, not plan advice. Confirm on Medicare.gov Plan Finder or 1-800-MEDICARE.
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2027 compared with 2026
Zenpep is number 79 by total Medicare Part D spending in 2024 ($597 million). Plans that list it most often put it on tier 4 (a tier is the cost level a plan puts a drug on; a lower tier usually costs less). Counts use 9 RxNorm products for this name.
| Measure | 2026 | 2027 | Change |
|---|---|---|---|
| Part D plans in the file | 5,518 | 5,495 | -23 |
| Plans that list it | 5,174 (94%) | 5,220 (95%) | +1 point |
| Prior authorization (of plans that list it) | 1 (<1%) | 1 (<1%) | no change |
| Step therapy (of plans that list it) | 0 (0%) | 0 (0%) | no change |
| Quantity limit (of plans that list it) | 0 (0%) | 0 (0%) | no change |
| Any of the three (of plans that list it) | 1 (<1%) | 1 (<1%) | no change |
| Not listed or restricted (of all plans) | 345 (6%) | 276 (5%) | -1 point |
Source: CMS 2027 Part D formulary file (basic drugs and plan information), as of October 8, 2026. Publisher page
Source: CMS 2026 Part D formulary file (basic drugs and plan information), as of September 30, 2026. Publisher page
Every 2027 stand-alone drug plan
Each stand-alone Part D plan (PDP) with Zenpep's 2027 tier and limits. CMS files a PDP once per region, so one plan name can have several plan IDs; the row shows the tier and limits most of them use. Medicare Advantage drug plans are local: pick a state for its plan-by-plan table.
| Plan (PDP) | Plan IDs | 2027 tier | 2027 limits |
|---|---|---|---|
| AARP Medicare Rx Preferred from UHC (PDP) | 39 | Tier 3 | None |
| AARP Medicare Rx Saver from UHC (PDP) | 34 | Tier 3 | None |
| Blue Medicare Rx Enhanced (PDP) | 1 | Tier 3 | None |
| Blue Medicare Rx Standard (PDP) | 1 | Tier 3 | None |
| Blue MedicareRx Essentials (PDP) | 1 | Tier 3 | None |
| Blue MedicareRx Plus (PDP) | 1 | Tier 3 | None |
| Blue MedicareRx Premier (PDP) | 1 | Tier 4 | None |
| Blue MedicareRx Value (PDP) | 1 | Tier 3 | None |
| Blue MedicareRx Value Plus (PDP) | 1 | Tier 4 | None |
| Blue Shield Rx Enhanced (PDP) | 1 | Tier 3 | None |
| Blue Shield Rx Plus (PDP) | 1 | Tier 3 | None |
| BlueMedicare Complete Rx (PDP) | 1 | Tier 3 | None |
| BlueMedicare Premier Rx (PDP) | 2 | Tier 4 | None (1 of 2 IDs) |
| BlueMedicare Value Rx (PDP) | 1 | Tier 4 | None |
| BlueRx Enhanced Plus (PDP) | 1 | Tier 3 | None |
| BlueRx Essential (PDP) | 1 | Tier 3 | None |
| HealthSpring Assurance Rx (PDP) | 35 | Tier 3 | None |
| HealthSpring Extra Rx (PDP) | 2 | Tier 3 | None |
| HealthSpring Extra RX (PDP) | 3 | Tier 3 | None |
| Horizon Medicare Blue Rx Enhanced (PDP) | 1 | Tier 3 | None |
| Horizon Medicare Blue Rx Standard (PDP) | 1 | Tier 3 | None |
| Humana Basic Rx Plan (PDP) | 34 | Tier 4 | None |
| Humana Premier Rx Plan (PDP) | 34 | Tier 4 | None |
| Humana Value Rx Plan (PDP) | 34 | Tier 4 | None |
| MedicareBlue Rx Standard (PDP) | 1 | Tier 3 | None |
| Prescription Blue Premium (PDP) | 1 | Tier 3 | None |
| Prescription Blue Select (PDP) | 1 | Tier 3 | None |
| SilverScript Choice (PDP) | 20 | Tier 4 | None |
| Wellcare Classic (PDP) | 34 | Tier 2 | None |
| Wellcare Value Script (PDP) | 34 | Tier 2 | None |
Source: CMS 2027 Part D formulary file (basic drugs and plan information), as of October 8, 2026. Publisher page
Source: CMS CY2027 landscape file (states and parent organizations), as of September 30, 2026. Publisher page
Formulary tier
| Tier | 2026 plans | 2027 plans |
|---|---|---|
| Tier 1 | 151 (3%) | 114 (2%) |
| Tier 2 | 52 (1%) | 313 (6%) |
| Tier 3 | 2,424 (47%) | 2,168 (42%) |
| Tier 4 | 2,547 (49%) | 2,625 (50%) |
Source: CMS 2027 Part D formulary file (basic drugs and plan information), as of October 8, 2026. Publisher page
Source: CMS 2026 Part D formulary file (basic drugs and plan information), as of September 30, 2026. Publisher page
Plan by plan, 2026 to 2027
4,380 plan IDs are in both files. 0 of them (0%) added prior authorization, step therapy, or a quantity limit for Zenpep, and 27 stopped listing it.
| Plan by plan | Plans |
|---|---|
| Same plan ID in both years | 4,380 |
| Listed it in 2026, not in 2027 | 27 (1%) |
| Listed it in 2027, not in 2026 | 133 (3%) |
| Moved it to a higher tier | 63 (1%) |
| Added prior authorization | 0 (0%) |
| Added step therapy | 0 (0%) |
| Added a quantity limit | 0 (0%) |
| Added at least one of the three | 0 (0%) |
| Removed at least one of the three | 0 (0%) |
| Plan IDs new in 2027 | 1,115 |
| 2026 plan IDs not in the 2027 file | 1,138 |
Source: CMS 2027 Part D formulary file (basic drugs and plan information), as of October 8, 2026. Publisher page
Source: CMS 2026 Part D formulary file (basic drugs and plan information), as of September 30, 2026. Publisher page
States from most to least restrictive
Share of 2027 Part D plans offered in each state that leave Zenpep off the formulary or list it with prior authorization, step therapy, or a quantity limit. Minnesota ranks first at 32%, with 0% of its plans using prior authorization or step therapy; 15 states tie for the lowest, 0%. States at the same share are ordered by the prior authorization or step therapy share; states equal on both shares share a rank, marked Tied.
| Rank | State | 2027 plans | Not listed or restricted | Prior auth or step therapy | Change from 2026 |
|---|---|---|---|---|---|
| 1 | Minnesota | 63 | 32% | 0% | +26 points |
| 2 | South Dakota | 30 | 27% | 0% | +17 points |
| 3 | North Dakota | 26 | 23% | 0% | +14 points |
| 4 | California | 397 | 18% | <1% | +4 points |
| 5 | Idaho | 45 | 18% | 0% | no change |
| 6 | Wisconsin | 97 | 13% | 0% | +1 point |
| 7 | New York | 215 | 8% | 0% | -1 point |
| Tied 8 | Montana | 27 | 7% | 0% | -1 point |
| Tied 8 | Michigan | 183 | 7% | 0% | -1 point |
| Tied 8 | Arizona | 148 | 7% | 0% | no change |
| Tied 11 | Nevada | 100 | 5% | 0% | -2 points |
| Tied 11 | Delaware | 43 | 5% | 0% | -7 points |
| Tied 11 | Ohio | 173 | 5% | 0% | -11 points |
| Tied 14 | New Mexico | 68 | 4% | 0% | -13 points |
| Tied 14 | Nebraska | 51 | 4% | 0% | -1 point |
| Tied 14 | Washington | 114 | 4% | 0% | -2 points |
| Tied 17 | Iowa | 64 | 3% | 0% | -2 points |
| Tied 17 | Florida | 549 | 3% | 0% | +2 points |
| Tied 17 | Texas | 412 | 3% | 0% | +1 point |
| Tied 17 | Indiana | 140 | 3% | 0% | -1 point |
| Tied 17 | Virginia | 145 | 3% | 0% | -2 points |
| Tied 17 | Tennessee | 157 | 3% | 0% | -2 points |
| Tied 23 | Kentucky | 123 | 2% | 0% | -1 point |
| Tied 23 | Kansas | 84 | 2% | 0% | -4 points |
| Tied 23 | South Carolina | 91 | 2% | 0% | -4 points |
| Tied 23 | Oregon | 92 | 2% | 0% | -1 point |
| Tied 23 | Connecticut | 54 | 2% | 0% | -4 points |
| Tied 23 | Pennsylvania | 324 | 2% | 0% | -10 points |
| Tied 23 | Missouri | 171 | 2% | 0% | -1 point |
| Tied 23 | North Carolina | 177 | 2% | 0% | -1 point |
| Tied 23 | Illinois | 133 | 2% | 0% | -1 point |
| Tied 32 | West Virginia | 70 | 1% | 0% | -5 points |
| Tied 32 | Arkansas | 86 | 1% | 0% | -2 points |
| Tied 32 | Colorado | 106 | 1% | 0% | -2 points |
| Tied 32 | Louisiana | 126 | 1% | 0% | -3 points |
| Tied 32 | Georgia | 151 | 1% | 0% | -2 points |
| Tied 37 | Alaska | 9 | 0% | 0% | -33 points |
| Tied 37 | Alabama | 115 | 0% | 0% | -3 points |
| Tied 37 | District of Columbia | 21 | 0% | 0% | -12 points |
| Tied 37 | Hawaii | 50 | 0% | 0% | -6 points |
| Tied 37 | Massachusetts | 92 | 0% | 0% | -3 points |
| Tied 37 | Maryland | 49 | 0% | 0% | -5 points |
| Tied 37 | Maine | 52 | 0% | 0% | -6 points |
| Tied 37 | Mississippi | 105 | 0% | 0% | -3 points |
| Tied 37 | New Hampshire | 25 | 0% | 0% | -12 points |
| Tied 37 | New Jersey | 74 | 0% | 0% | -4 points |
| Tied 37 | Oklahoma | 81 | 0% | 0% | -4 points |
| Tied 37 | Rhode Island | 29 | 0% | 0% | -10 points |
| Tied 37 | Utah | 53 | 0% | 0% | -5 points |
| Tied 37 | Vermont | 14 | 0% | 0% | -23 points |
| Tied 37 | Wyoming | 13 | 0% | 0% | -16 points |
Source: CMS CY2027 landscape file (states and parent organizations), as of September 30, 2026. Publisher page
Source: CMS 2027 Part D formulary file (basic drugs and plan information), as of October 8, 2026. Publisher page
By parent organization
164 parent organizations offer 2027 Part D plans. Humana Inc. has the most, 884, and 0% of them leave Zenpep off or restrict it.
| Parent organization | 2027 plans ↓ | List it | Restrict it (of listing) | Not listed or restricted | Change from 2026 | Plans that added a restriction |
|---|---|---|---|---|---|---|
| DOCTORS HEALTHCARE PLANS, INC. | 9 | 100% | 0% | 0% | no change | 0 |
| EmblemHealth, Inc. | 9 | 100% | 0% | 0% | no change | 0 |
| Perennial Consortium, LLC | 9 | 100% | 0% | 0% | no change | 0 |
| West Virginia United Health System, Inc. | 9 | 100% | 0% | 0% | no change | 0 |
| Astiva Health Holdings Incorporated | 8 | 100% | 0% | 0% | no change | 0 |
| Healthfirst, Inc. | 8 | 100% | 0% | 0% | no change | 0 |
| Longevity Health Founders, LLC | 8 | 100% | 0% | 0% | no change | 0 |
| MVP Health Care, Inc. | 8 | 100% | 0% | 0% | no change | 0 |
| Martin's Point Health Care, Inc. | 8 | 100% | 0% | 0% | no change | 0 |
| Triton Health Systems, L.L.C. | 8 | 100% | 0% | 0% | no change | 0 |
| Allina Health and Aetna Insurance Holding Company | 7 | 71% | 0% | 29% | +7 points | 0 |
| Baylor Scott & White Health | 7 | 100% | 0% | 0% | no change | 0 |
| Blue Cross and Blue Shield of Massachusetts, Inc. | 7 | 100% | 0% | 0% | no change | 0 |
| HealthPartners, Inc. | 7 | 0% | none list it | 100% | +100 points | 0 |
| Johns Hopkins Healthcare LLC | 7 | 100% | 0% | 0% | no change | 0 |
| Network Health, Inc. | 7 | 0% | none list it | 100% | no change | 0 |
| Singh Holdings LLC | 7 | 100% | 0% | 0% | no change | 0 |
| Baystate Health, Inc. | 6 | 100% | 0% | 0% | no change | 0 |
| Blue Cross Blue Shield of Arizona | 6 | 100% | 0% | 0% | no change | 0 |
| Blue Cross Blue Shield of Kansas | 6 | 100% | 0% | 0% | no change | 0 |
| BlueCross BlueShield of South Carolina (BCBSSC) | 6 | 100% | 0% | 0% | no change | 0 |
| CareSource | 6 | 100% | 0% | 0% | no change | 0 |
| Clever Care Health Plan, Inc. | 6 | 100% | 0% | 0% | no change | 0 |
| Eternal Health of Delaware, Inc. | 6 | 100% | 0% | 0% | no change | 0 |
| Hawaii Medical Service Association | 6 | 100% | 0% | 0% | no change | 0 |
Source: CMS CY2027 landscape file (states and parent organizations), as of September 30, 2026. Publisher page
Source: CMS 2027 Part D formulary file (basic drugs and plan information), as of October 8, 2026. Publisher page
Other Lipase/Protease/Amylase products
Near it by Part D spending
About this data
A plan here is one Part D plan as the CMS formulary files list it: contract, plan, and segment. That covers Medicare Advantage plans with drug coverage and stand-alone drug plans. A plan lists a drug when its formulary has a row for any RxNorm product of that name. When it has several, the row with the lowest tier is the one counted, and restricted means that row has prior authorization, step therapy, or a quantity limit.
A plan with no row for the drug counts as not listing it. That can be a product the file codes another way, so read a low count as a lookup result, not a coverage decision. A state counts every plan the CMS landscape file offers there. Parent organizations are named as CMS names them. The drug list is the top 200 by total Part D spending.
Source: CMS 2027 Part D formulary file (basic drugs and plan information), as of October 8, 2026. Publisher page
Source: CMS CY2027 landscape file (states and parent organizations), as of September 30, 2026. Publisher page
Source: CMS Medicare Part D Spending by Drug, 2024 data, as of June 25, 2026. Publisher page