Medicare drug coverage

Creon: 2027 Medicare Part D coverage

5,307 of 5,495 Part D plans (97%) list Creon on their 2027 formulary, down 1 point from 2026. 0% of those require prior authorization, step therapy, or a quantity limit.

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2027 compared with 2026

Creon is number 34 by total Medicare Part D spending in 2024 ($1.5 billion). Plans that list it most often put it on tier 3. Counts use 6 RxNorm products for this name.

Creon Part D coverage, 2026 and 2027
Measure20262027Change
Part D plans in the file5,5185,495-23
Plans that list it5,368 (97%)5,307 (97%)-1 point
Prior authorization (of plans that list it)1 (0%)1 (0%)no change
Step therapy (of plans that list it)0 (0%)0 (0%)no change
Quantity limit (of plans that list it)0 (0%)0 (0%)no change
Any of the three (of plans that list it)1 (0%)1 (0%)no change
Not listed or restricted (of all plans)151 (3%)189 (3%)+1 point

Source: CMS 2027 Part D formulary file (basic drugs and plan information), as of October 8, 2026. Publisher page

Source: CMS 2026 Part D formulary file (basic drugs and plan information), as of September 30, 2026. Publisher page

Formulary tier

Creon formulary tier, 2026 and 2027
Tier2026 plans2027 plans
Tier 1163 (3%)123 (2%)
Tier 252 (1%)245 (5%)
Tier 35,125 (95%)4,909 (93%)
Tier 428 (1%)30 (1%)

Source: CMS 2027 Part D formulary file (basic drugs and plan information), as of October 8, 2026. Publisher page

Source: CMS 2026 Part D formulary file (basic drugs and plan information), as of September 30, 2026. Publisher page

Plan by plan, 2026 to 2027

4,380 plan ids are in both files. 0 of them (0%) added prior authorization, step therapy, or a quantity limit for Creon, and 55 stopped listing it.

Creon: plans in both 2026 and 2027
Plan by planPlans
Same plan id in both years4,380
Listed it in 2026, not in 202755 (1%)
Listed it in 2027, not in 20260 (0%)
Moved it to a higher tier66 (2%)
Added prior authorization0 (0%)
Added step therapy0 (0%)
Added a quantity limit0 (0%)
Added at least one of the three0 (0%)
Removed at least one of the three0 (0%)
Plan ids new in 20271,115
2026 plan ids not in the 2027 file1,138

Source: CMS 2027 Part D formulary file (basic drugs and plan information), as of October 8, 2026. Publisher page

Source: CMS 2026 Part D formulary file (basic drugs and plan information), as of September 30, 2026. Publisher page

States from most to least restrictive

Share of 2027 Part D plans offered in each state that leave Creon off the formulary or list it with prior authorization, step therapy, or a quantity limit. Wyoming ranks first at 38%, with 0% of its plans using prior authorization or step therapy; Texas ranks last at 0%. Ties break on the prior authorization or step therapy share.

States from most to least restrictive for Creon, 2027
RankState2027 plansNot listed or restrictedPrior auth or step therapyChange from 2026
1Wyoming1338%0%+12 points
2Rhode Island2924%0%+14 points
3Michigan18323%0%-1 point
4Alaska922%0%-11 points
5Minnesota6319%0%+15 points
6Vermont1414%0%-9 points
7Nebraska5112%0%+6 points
8North Dakota2612%0%-4 points
9Idaho4511%0%+5 points
10Montana2711%0%+3 points
11South Dakota3010%0%no change
12District of Columbia2110%0%-2 points
13New Hampshire258%0%-4 points
14Florida5498%0%+7 points
15New York2155%0%+4 points
16Kansas845%0%+1 point
17Iowa645%0%no change
18Delaware435%0%-2 points
19Alabama1154%0%+1 point
20Maryland494%0%-1 point
21New Jersey744%0%+1 point
22Hawaii504%0%no change
23Maine524%0%-2 points
24Utah534%0%-1 point
25Connecticut544%0%-2 points
26New Mexico683%0%-1 point
27West Virginia703%0%-1 point
28Tennessee1573%0%no change
29Oklahoma812%0%-1 point
30Arkansas862%0%-1 point
31South Carolina912%0%-1 point
32Massachusetts922%0%-1 point
33Oregon922%0%-1 point
34Wisconsin972%0%-2 points
35Nevada1002%0%-1 point
36Mississippi1052%0%-1 point
37Colorado1062%0%-1 point
38Washington1142%0%-1 point
39Kentucky1232%0%-1 point
40Louisiana1262%0%-1 point
41Illinois1332%0%no change
42Indiana1401%0%-1 point
43Virginia1451%0%-1 point
44Arizona1481%0%-1 point
45Georgia1511%0%-1 point
46Missouri1711%0%-1 point
47Ohio1731%0%no change
48North Carolina1771%0%-1 point
49California3971%0%no change
50Pennsylvania3241%0%no change
51Texas4120%0%no change

Source: CMS CY2027 landscape file (states and parent organizations), as of September 30, 2026. Publisher page

Source: CMS 2027 Part D formulary file (basic drugs and plan information), as of October 8, 2026. Publisher page

By parent organization

164 parent organizations offer 2027 Part D plans. Humana Inc. has the most, 884, and 0% of them leave Creon off or restrict it.

Creon coverage by parent organization, 2027
Parent organization2027 plans ↓List itRestrict it (of listing)Not listed or restrictedChange from 2026Plans that added a restriction
Humana Inc.884100%0%0%no change0
UnitedHealth Group, Inc.850100%0%0%no change0
Devoted Health, Inc.728100%0%0%no change0
CVS Health Corporation633100%0%0%no change0
Elevance Health, Inc.294100%0%0%no change0
Centene Corporation26875%0%25%+5 points0
Health Care Service Corporation231100%0%0%-10 points0
Kaiser Foundation Health Plan, Inc.112100%0%0%no change0
Highmark Health98100%0%0%no change0
SCAN Group85100%0%0%no change0
Alignment Healthcare USA, LLC77100%0%0%no change0
Guidewell Mutual Holding Corporation5535%0%65%+65 points0
Blue Cross Blue Shield of Michigan Mutual Ins. Co.430%none list it100%+6 points0
Molina Healthcare, Inc.43100%0%0%no change0
Corewell Health40100%0%0%no change0
Zing Health Consolidator, Inc36100%0%0%no change0
CAPITAL BLUE CROSS35100%0%0%no change0
Medica Holding Company31100%0%0%no change0
UPMC Health System30100%0%0%no change0
Universal Health Services, Inc.29100%0%0%no change0
MHH Healthcare, L.P.26100%0%0%no change0
Independence Health Group, Inc.25100%0%0%no change0
Point32Health, Inc.23100%0%0%no change0
BlueCross BlueShield of Tennessee22100%0%0%no change0
California Physicians' Service22100%0%0%no change0

Source: CMS CY2027 landscape file (states and parent organizations), as of September 30, 2026. Publisher page

Source: CMS 2027 Part D formulary file (basic drugs and plan information), as of October 8, 2026. Publisher page

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Tier changes and new prior auth, step therapy or quantity limits, plan by plan, before open enrollment.

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Other Lipase/Protease/Amylase products

Near it by Part D spending

About this data

A plan here is one Part D plan as the CMS formulary files list it: contract, plan, and segment. That covers Medicare Advantage plans with drug coverage and stand-alone drug plans. A plan lists a drug when its formulary has a row for any RxNorm product of that name. When it has several, the row with the lowest tier is the one counted, and restricted means that row has prior authorization, step therapy, or a quantity limit.

A plan with no row for the drug counts as not listing it. That can be a product the file codes another way, so read a low count as a lookup result, not a coverage decision. A state counts every plan the CMS landscape file offers there. Parent organizations are named as CMS names them. The drug list is the top 200 by total Part D spending.

Source: CMS 2027 Part D formulary file (basic drugs and plan information), as of October 8, 2026. Publisher page

Source: CMS CY2027 landscape file (states and parent organizations), as of September 30, 2026. Publisher page

Source: CMS Medicare Part D Spending by Drug, 2024 data, as of June 25, 2026. Publisher page

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