Medicare drug coverage
Zenpep: 2027 Medicare Part D coverage
5,220 of 5,495 Part D plans (95%) list Zenpep on their 2027 formulary, up 1 point from 2026. 0% of those require prior authorization, step therapy, or a quantity limit.
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2027 compared with 2026
Zenpep is number 79 by total Medicare Part D spending in 2024 ($597 million). Plans that list it most often put it on tier 4. Counts use 9 RxNorm products for this name.
| Measure | 2026 | 2027 | Change |
|---|---|---|---|
| Part D plans in the file | 5,518 | 5,495 | -23 |
| Plans that list it | 5,174 (94%) | 5,220 (95%) | +1 point |
| Prior authorization (of plans that list it) | 1 (0%) | 1 (0%) | no change |
| Step therapy (of plans that list it) | 0 (0%) | 0 (0%) | no change |
| Quantity limit (of plans that list it) | 0 (0%) | 0 (0%) | no change |
| Any of the three (of plans that list it) | 1 (0%) | 1 (0%) | no change |
| Not listed or restricted (of all plans) | 345 (6%) | 276 (5%) | -1 point |
Source: CMS 2027 Part D formulary file (basic drugs and plan information), as of October 8, 2026. Publisher page
Source: CMS 2026 Part D formulary file (basic drugs and plan information), as of September 30, 2026. Publisher page
Formulary tier
| Tier | 2026 plans | 2027 plans |
|---|---|---|
| Tier 1 | 151 (3%) | 114 (2%) |
| Tier 2 | 52 (1%) | 313 (6%) |
| Tier 3 | 2,424 (47%) | 2,168 (42%) |
| Tier 4 | 2,547 (49%) | 2,625 (50%) |
Source: CMS 2027 Part D formulary file (basic drugs and plan information), as of October 8, 2026. Publisher page
Source: CMS 2026 Part D formulary file (basic drugs and plan information), as of September 30, 2026. Publisher page
Plan by plan, 2026 to 2027
4,380 plan ids are in both files. 0 of them (0%) added prior authorization, step therapy, or a quantity limit for Zenpep, and 27 stopped listing it.
| Plan by plan | Plans |
|---|---|
| Same plan id in both years | 4,380 |
| Listed it in 2026, not in 2027 | 27 (1%) |
| Listed it in 2027, not in 2026 | 133 (3%) |
| Moved it to a higher tier | 63 (1%) |
| Added prior authorization | 0 (0%) |
| Added step therapy | 0 (0%) |
| Added a quantity limit | 0 (0%) |
| Added at least one of the three | 0 (0%) |
| Removed at least one of the three | 0 (0%) |
| Plan ids new in 2027 | 1,115 |
| 2026 plan ids not in the 2027 file | 1,138 |
Source: CMS 2027 Part D formulary file (basic drugs and plan information), as of October 8, 2026. Publisher page
Source: CMS 2026 Part D formulary file (basic drugs and plan information), as of September 30, 2026. Publisher page
States from most to least restrictive
Share of 2027 Part D plans offered in each state that leave Zenpep off the formulary or list it with prior authorization, step therapy, or a quantity limit. Minnesota ranks first at 32%, with 0% of its plans using prior authorization or step therapy; Wyoming ranks last at 0%. Ties break on the prior authorization or step therapy share.
| Rank | State | 2027 plans | Not listed or restricted | Prior auth or step therapy | Change from 2026 |
|---|---|---|---|---|---|
| 1 | Minnesota | 63 | 32% | 0% | +25 points |
| 2 | South Dakota | 30 | 27% | 0% | +17 points |
| 3 | North Dakota | 26 | 23% | 0% | +14 points |
| 4 | California | 397 | 18% | 0% | +4 points |
| 5 | Idaho | 45 | 18% | 0% | no change |
| 6 | Wisconsin | 97 | 13% | 0% | +1 point |
| 7 | New York | 215 | 8% | 0% | -1 point |
| 8 | Montana | 27 | 7% | 0% | -1 point |
| 9 | Michigan | 183 | 7% | 0% | -1 point |
| 10 | Arizona | 148 | 7% | 0% | -1 point |
| 11 | Nevada | 100 | 5% | 0% | -2 points |
| 12 | Delaware | 43 | 5% | 0% | -7 points |
| 13 | Ohio | 173 | 5% | 0% | -11 points |
| 14 | New Mexico | 68 | 4% | 0% | -12 points |
| 15 | Nebraska | 51 | 4% | 0% | -2 points |
| 16 | Washington | 114 | 4% | 0% | -2 points |
| 17 | Iowa | 64 | 3% | 0% | -1 point |
| 18 | Florida | 549 | 3% | 0% | +2 points |
| 19 | Texas | 412 | 3% | 0% | no change |
| 20 | Indiana | 140 | 3% | 0% | -1 point |
| 21 | Virginia | 145 | 3% | 0% | -2 points |
| 22 | Tennessee | 157 | 3% | 0% | -3 points |
| 23 | Kentucky | 123 | 2% | 0% | no change |
| 24 | Kansas | 84 | 2% | 0% | -3 points |
| 25 | South Carolina | 91 | 2% | 0% | -4 points |
| 26 | Oregon | 92 | 2% | 0% | -1 point |
| 27 | Connecticut | 54 | 2% | 0% | -4 points |
| 28 | Pennsylvania | 324 | 2% | 0% | -10 points |
| 29 | Missouri | 171 | 2% | 0% | -1 point |
| 30 | North Carolina | 177 | 2% | 0% | -1 point |
| 31 | Illinois | 133 | 2% | 0% | -2 points |
| 32 | West Virginia | 70 | 1% | 0% | -4 points |
| 33 | Arkansas | 86 | 1% | 0% | -2 points |
| 34 | Colorado | 106 | 1% | 0% | -2 points |
| 35 | Louisiana | 126 | 1% | 0% | -3 points |
| 36 | Georgia | 151 | 1% | 0% | -3 points |
| 37 | Alaska | 9 | 0% | 0% | -33 points |
| 38 | Alabama | 115 | 0% | 0% | -3 points |
| 39 | District of Columbia | 21 | 0% | 0% | -12 points |
| 40 | Hawaii | 50 | 0% | 0% | -6 points |
| 41 | Massachusetts | 92 | 0% | 0% | -3 points |
| 42 | Maryland | 49 | 0% | 0% | -5 points |
| 43 | Maine | 52 | 0% | 0% | -6 points |
| 44 | Mississippi | 105 | 0% | 0% | -3 points |
| 45 | New Hampshire | 25 | 0% | 0% | -12 points |
| 46 | New Jersey | 74 | 0% | 0% | -4 points |
| 47 | Oklahoma | 81 | 0% | 0% | -4 points |
| 48 | Rhode Island | 29 | 0% | 0% | -10 points |
| 49 | Utah | 53 | 0% | 0% | -5 points |
| 50 | Vermont | 14 | 0% | 0% | -23 points |
| 51 | Wyoming | 13 | 0% | 0% | -16 points |
Source: CMS CY2027 landscape file (states and parent organizations), as of September 30, 2026. Publisher page
Source: CMS 2027 Part D formulary file (basic drugs and plan information), as of October 8, 2026. Publisher page
By parent organization
164 parent organizations offer 2027 Part D plans. Humana Inc. has the most, 884, and 0% of them leave Zenpep off or restrict it.
| Parent organization | 2027 plans ↓ | List it | Restrict it (of listing) | Not listed or restricted | Change from 2026 | Plans that added a restriction |
|---|---|---|---|---|---|---|
| Humana Inc. | 884 | 100% | 0% | 0% | -11 points | 0 |
| UnitedHealth Group, Inc. | 850 | 100% | 0% | 0% | no change | 0 |
| Devoted Health, Inc. | 728 | 100% | 0% | 0% | no change | 0 |
| CVS Health Corporation | 633 | 88% | 0% | 12% | +6 points | 0 |
| Elevance Health, Inc. | 294 | 94% | 0% | 6% | no change | 0 |
| Centene Corporation | 268 | 100% | 0% | 0% | no change | 0 |
| Health Care Service Corporation | 231 | 100% | 0% | 0% | no change | 0 |
| Kaiser Foundation Health Plan, Inc. | 112 | 100% | 0% | 0% | no change | 0 |
| Highmark Health | 98 | 100% | 0% | 0% | no change | 0 |
| SCAN Group | 85 | 0% | none list it | 100% | no change | 0 |
| Alignment Healthcare USA, LLC | 77 | 100% | 0% | 0% | no change | 0 |
| Guidewell Mutual Holding Corporation | 55 | 69% | 0% | 31% | -10 points | 0 |
| Blue Cross Blue Shield of Michigan Mutual Ins. Co. | 43 | 100% | 0% | 0% | no change | 0 |
| Molina Healthcare, Inc. | 43 | 100% | 0% | 0% | no change | 0 |
| Corewell Health | 40 | 100% | 0% | 0% | no change | 0 |
| Zing Health Consolidator, Inc | 36 | 100% | 0% | 0% | no change | 0 |
| CAPITAL BLUE CROSS | 35 | 100% | 0% | 0% | no change | 0 |
| Medica Holding Company | 31 | 16% | 0% | 84% | +84 points | 0 |
| UPMC Health System | 30 | 100% | 0% | 0% | -100 points | 0 |
| Universal Health Services, Inc. | 29 | 100% | 0% | 0% | no change | 0 |
| MHH Healthcare, L.P. | 26 | 100% | 0% | 0% | no change | 0 |
| Independence Health Group, Inc. | 25 | 100% | 0% | 0% | no change | 0 |
| Point32Health, Inc. | 23 | 100% | 0% | 0% | no change | 0 |
| BlueCross BlueShield of Tennessee | 22 | 100% | 0% | 0% | no change | 0 |
| California Physicians' Service | 22 | 100% | 0% | 0% | no change | 0 |
Source: CMS CY2027 landscape file (states and parent organizations), as of September 30, 2026. Publisher page
Source: CMS 2027 Part D formulary file (basic drugs and plan information), as of October 8, 2026. Publisher page
Run it in Rivvi
Which 2027 plans near you dropped or restricted Zenpep?
Tier changes and new prior auth, step therapy or quantity limits, plan by plan, before open enrollment.
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Other Lipase/Protease/Amylase products
Near it by Part D spending
About this data
A plan here is one Part D plan as the CMS formulary files list it: contract, plan, and segment. That covers Medicare Advantage plans with drug coverage and stand-alone drug plans. A plan lists a drug when its formulary has a row for any RxNorm product of that name. When it has several, the row with the lowest tier is the one counted, and restricted means that row has prior authorization, step therapy, or a quantity limit.
A plan with no row for the drug counts as not listing it. That can be a product the file codes another way, so read a low count as a lookup result, not a coverage decision. A state counts every plan the CMS landscape file offers there. Parent organizations are named as CMS names them. The drug list is the top 200 by total Part D spending.
Source: CMS 2027 Part D formulary file (basic drugs and plan information), as of October 8, 2026. Publisher page
Source: CMS CY2027 landscape file (states and parent organizations), as of September 30, 2026. Publisher page
Source: CMS Medicare Part D Spending by Drug, 2024 data, as of June 25, 2026. Publisher page