FDA label
What is Entresto used for?
Entresto contains sacubitril and valsartan. The FDA-approved uses below are quoted from the Indications and Usage section of its DailyMed label.
Source: DailyMed SPL label file dated 2026-10-23. Publisher page
The FDA label for Entresto lists 2 uses: Adult Heart Failure; Pediatric Heart Failure.
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Entresto, tablet, film coated
Indications and Usage, quoted from the label by Novartis Pharmaceuticals Corporation (NDA207620). Cross-references to other label sections are left out.
Adult Heart Failure
ENTRESTO is indicated to reduce the risk of cardiovascular death and hospitalization for heart failure in adult patients with chronic heart failure. Benefits are most clearly evident in patients with left ventricular ejection fraction (LVEF) below normal.
LVEF is a variable measure, so use clinical judgment in deciding whom to treat.
Pediatric Heart Failure
ENTRESTO is indicated for the treatment of symptomatic heart failure with systemic left ventricular systolic dysfunction in pediatric patients aged one year and older. ENTRESTO reduces NT-proBNP and is expected to improve cardiovascular outcomes.
Source: DailyMed label, set id 000dc81d-ab91-450c-8eae-8eb74e72296f, version 25, effective July 6, 2026. NDC 0078-0659, one of 8 listings for this product.
Questions
What is Entresto used for?
The FDA label for Entresto lists 2 uses: Adult Heart Failure; Pediatric Heart Failure.
What drug class is Entresto?
FDA lists sacubitril and valsartan in the Angiotensin 2 Receptor Blocker and Neprilysin Inhibitor established pharmacologic class.
Does this page cover off-label uses or dosing?
No. This page shows only the Indications and Usage section of the FDA label. Ask a pharmacist or prescriber about dosing.
More on Entresto
- Is Entresto a controlled substance?Federal schedule
- Generic for EntrestoFDA Orange Book
- Generic for Entresto SprinkleFDA Orange Book
- Angiotensin 2 Receptor Blockers listFDA drug class
- Neprilysin Inhibitors listFDA drug class
- Entresto Medicare Part D coverageBy plan and state
- NDC 0078-0659Entresto NDC record
- NDC 0078-0696Entresto NDC record
- NDC 0078-0777Entresto NDC record