FDA label
What is Xgeva used for?
Xgeva contains denosumab. The FDA-approved uses below are quoted from the Indications and Usage section of its DailyMed label.
Source: DailyMed SPL label file dated 2026-10-23. Publisher page
The FDA label for Xgeva lists 3 uses: Multiple Myeloma and Bone Metastasis from Solid Tumors; Giant Cell Tumor of Bone; Hypercalcemia of Malignancy.
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Xgeva, injection
Indications and Usage, quoted from the label by Amgen, Inc (BLA125320). Cross-references to other label sections are left out.
Multiple Myeloma and Bone Metastasis from Solid Tumors
Xgeva is indicated for the prevention of skeletal-related events in patients with multiple myeloma and in patients with bone metastases from solid tumors.
Giant Cell Tumor of Bone
Xgeva is indicated for the treatment of adults and skeletally mature adolescents with giant cell tumor of bone that is unresectable or where surgical resection is likely to result in severe morbidity.
Hypercalcemia of Malignancy
Xgeva is indicated for the treatment of hypercalcemia of malignancy refractory to bisphosphonate therapy.
Source: DailyMed label, set id 628f0998-1206-4001-aeee-18133aa9f3bf, version 177, effective June 23, 2026. NDC 55513-730, one of 1 listing for this product.
Questions
What is Xgeva used for?
The FDA label for Xgeva lists 3 uses: Multiple Myeloma and Bone Metastasis from Solid Tumors; Giant Cell Tumor of Bone; Hypercalcemia of Malignancy.
What drug class is Xgeva?
FDA lists denosumab in the RANK Ligand Inhibitor established pharmacologic class.
Does this page cover off-label uses or dosing?
No. This page shows only the Indications and Usage section of the FDA label. Ask a pharmacist or prescriber about dosing.