FDA Orange Book
Is there a generic for Yuvezzi?
Yuvezzi contains carbachol and brimonidine. Orange Book status for every listed strength, the approved generic makers, and the listed patents and exclusivities.
Source: FDA Orange Book data file dated 2026-10-09. Publisher page
No. The Orange Book lists no active FDA-approved generic (ANDA) for Yuvezzi (carbachol and brimonidine). The Orange Book shows its last listed patent expires November 10, 2042 and its last listed exclusivity ends January 28, 2029.
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Yuvezzi products in the Orange Book
| Form and route | Strength | Brand status | Brand TE | Active generics | Generic TE codes |
|---|---|---|---|---|---|
| solution/drops, ophthalmic | 0.1%;2.75% | Marketed (Rx) | None | 0 | None |
NDA 220142, held by VISUS THERAPEUTICS INC. Active generics are ANDA products in the Orange Book prescription list with the same ingredient, dosage form, route and strength.
Yuvezzi patents
| Patent | Expires | Covers | Use code | NDA |
|---|---|---|---|---|
| 8455494 | May 24, 2030 | Method of use | U-3741 | 220142 |
| 8455494 | May 24, 2030 | Method of use | U-4419 | 220142 |
| 8455494 | May 24, 2030 | Method of use | U-4420 | 220142 |
| 12268662 | November 10, 2042 | Drug product | U-3741 | 220142 |
| 12268662 | November 10, 2042 | Drug product | U-4419 | 220142 |
| 12268662 | November 10, 2042 | Drug product | U-4420 | 220142 |
Yuvezzi exclusivity
| Code | Meaning | Expires | NDA |
|---|---|---|---|
| NP | New product | January 28, 2029 | 220142 |
Yuvezzi NDC codes
Questions
Is there a generic for Yuvezzi?
No. The Orange Book lists no active FDA-approved generic (ANDA) for Yuvezzi (carbachol and brimonidine). The Orange Book shows its last listed patent expires November 10, 2042 and its last listed exclusivity ends January 28, 2029.
What is the generic name for Yuvezzi?
The active ingredient in Yuvezzi is carbachol and brimonidine, per the FDA Orange Book.
When does the Yuvezzi patent expire?
The last patent listed for Yuvezzi in the Orange Book expires November 10, 2042. A listed patent expiry date is not a generic launch date.
What does a therapeutic equivalence code mean?
In the Orange Book, codes that start with A (such as AB) mean FDA considers the product therapeutically equivalent to the reference drug. Codes that start with B mean FDA does not, at this time, consider the product therapeutically equivalent.