HCPCS Level II modifier

Modifier TB

Modifier TB is a HCPCS Level II modifier. CMS describes it as: Drug or biological acquired with 340b drug pricing program discount, reported for informational purposes.

Source: CMS HCPCS Level II, October 2026 file dated September 23, 2026. Publisher page

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Modifier
TB
Type
HCPCS Level II modifier, maintained by CMS
CMS description
Drug or biological acquired with 340b drug pricing program discount, reported for informational purposes
Claim form
CMS-1500 item 24D, up to four modifiers per line. 837P SV101-3 to SV101-6.

Drug waste and 340B

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Questions

What does modifier TB mean?

Modifier TB is a HCPCS Level II modifier. CMS describes it as: Drug or biological acquired with 340b drug pricing program discount, reported for informational purposes.

Is modifier TB a CPT or a HCPCS modifier?

TB is a HCPCS Level II modifier from the CMS quarterly HCPCS file. Two-digit numeric modifiers, such as 25 or 59, are CPT modifiers.

Where does modifier TB go on a claim?

On the CMS-1500 it goes in item 24D next to the procedure code. Each line holds up to four modifiers. On an 837P it goes in SV101-3 to SV101-6.

What denial comes back when a modifier is wrong?

A missing or mismatched modifier often comes back as CARC 4. A modifier that was not valid on the date of service comes back as CARC 182. A bundling edit the modifier should have bypassed comes back as CARC 97 or 236.

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