FDA drug class
Opioid Agonists list
Every FDA-approved prescription drug the FDA NDC directory tags with the Opioid Agonist [EPC] class, with brand names and DEA schedules.
Source: FDA NDC Directory file dated 2026-10-22. Publisher page
The FDA NDC directory lists 15 single-ingredient drugs in this class: codeine, fentanyl, hydrocodone, hydromorphone, levorphanol, loperamide, meperidine, methadone, and more. Another 14 combination products include one of them.
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Opioid Agonists (29)
| Drug | Brand names | Type | NDC listings | DEA schedule |
|---|---|---|---|---|
| Codeine | None listed | Single ingredient | 6 | Schedule II |
| Fentanyl | None listed | Single ingredient | 54 | Schedule II |
| Hydrocodone | Hysingla ER | Single ingredient | 19 | Schedule II |
| Hydromorphone | Dilaudid | Single ingredient | 71 | Schedule II |
| Levorphanol | None listed | Single ingredient | 10 | Schedule II |
| Loperamide | None listed | Single ingredient | 43 | Not controlled |
| Meperidine | Demerol | Single ingredient | 10 | Schedule II |
| Methadone | Methadose, Diskets | Single ingredient | 50 | Schedule II |
| Morphine | MS Contin, Duramorph, Infumorph 200, Infumorph 500 | Single ingredient | 142 | Schedule II |
| Oxycodone | OxyContin, Roxicodone, RoxyBond, Oxaydo | Single ingredient | 161 | Schedule II |
| Oxymorphone | None listed | Single ingredient | 27 | Schedule II |
| Remifentanil | Ultiva | Single ingredient | 13 | Schedule II |
| Sufentanil | None listed | Single ingredient | 1 | Schedule II |
| Tapentadol | Nucynta | Single ingredient | 26 | Schedule II |
| Tramadol | ConZip | Single ingredient | 128 | Schedule IV |
| Acetaminophen and codeine | None listed | Combination | 75 | Schedule III or V |
| Acetaminophen, caffeine and dihydrocodeine | Trezix | Combination | 1 | Schedule III |
| Butalbital, acetaminophen, caffeine and codeine | None listed | Combination | 8 | Schedule III |
| Butalbital, aspirin, caffeine and codeine | Ascomp with Codeine | Combination | 4 | Schedule III |
| Codeine and chlorpheniramine | Tuxarin | Combination | 1 | Schedule III |
| Hydrocodone and acetaminophen | Norco | Combination | 209 | Schedule II |
| Hydrocodone and chlorpheniramine | None listed | Combination | 3 | Schedule II |
| Hydrocodone and homatropine methylbromide | None listed | Combination | 8 | Schedule II |
| Hydrocodone and ibuprofen | None listed | Combination | 5 | Schedule II |
| Oxycodone and acetaminophen | Endocet, Percocet, Prolate, Nalocet | Combination | 136 | Schedule II |
| Oxycodone and aspirin | None listed | Combination | 1 | Schedule II |
| Promethazine and codeine | None listed | Combination | 5 | Schedule V |
| Promethazine, phenylephrine and codeine | None listed | Combination | 1 | Schedule V |
| Tramadol and acetaminophen | None listed | Combination | 16 | Schedule IV |
FDA established pharmacologic class: Opioid Agonist [EPC].
Questions
What drugs are Opioid Agonists?
The FDA NDC directory lists 15 single-ingredient drugs in this class: codeine, fentanyl, hydrocodone, hydromorphone, levorphanol, loperamide, meperidine, methadone, and more. Another 14 combination products include one of them.
Where does this list come from?
From the established pharmacologic class (EPC) field FDA publishes for each listing in the NDC directory. A drug is listed when most of its prescription listings carry the class.
Related
- CodeineFDA label
- FentanylFDA label
- HydrocodoneHysingla ER
- HydromorphoneDilaudid
- LevorphanolFDA label
- LoperamideFDA label
- MeperidineDemerol
- MethadoneMethadose, Diskets
- All drug classesFDA EPC
- Controlled substances by scheduleDEA list
- Generic drug lookupFDA Orange Book
- NDC lookupFDA NDC directory
- Medicare Part D drug coverageBy plan and state